DB2 adapter registry issue

After installing Host Integration Server 2013 Developer Edition on top of BizTalk 2013, the DB2 adapter was created in BizTalk Admin console. However, after configuring receive location and/or send port with DB2 adapter, the BizTalk Admin console displayed below error:   A message sent to adapter “BiztalkMessagingEngine” on send port “SendPort4” with URI “DB2://XXX.XXX.XXX.XXX:446/XXXXXXX/XXXXXXX” is…